Physicians' Academy for Cardiovascular Education

Association of blood pressure variability with CV risk is irrespective of CV baseline risk

Blood pressure variability and risk of cardiovascular events and death in patients with hypertension and different baseline risks

Mehlum MH, Liestøl K, Kjeldsen SE, et al. - Eur Heart J 2018; published online ahead of print


Clinical and observational studies show that increased blood pressure (BP) variability contributes to the risk CV events and death, independently of the mean BP, particularly in high-risk patients [1,2]. In this analysis of the Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial, the CV risk associated with increased BP variability was evaluated in patients at different risk levels of baseline CV risk and whether the association was modified by any other factor.

In the VALUE trial, 15,245 patients with hypertension and at least one additional CV risk factor, were randomized to receive amlodipine 5 or 10 mg or valsartan 80 or 160 mg, on top of other BP lowering treatments, in order to reach the BP target of < 140/90 mmHg [3]. The target population for the present analysis consisted of patients without a CV event during the first 6 months of the study, who participated at a minimum of 3 visits from Visit 6 onwards (N=13,803).

The per-protocol population was defined as patients who had ≥3 per-protocol visits, i.e. visits with no pause in the allocated treatment during the 30 days before the visit. The classification of the CV risk was based on the Joint ESC Guidelines for classifying risk [4]. The primary effect variable was the time to the first composite CV endpoint of a cardiac event or stroke.

Main results


Patients with hypertension and higher BP variability are at increased risk of CV events as compared with those with low BP variability, irrespective of CV baseline risk. The association is stronger in younger patients, and those with a lower BP.


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Find this article online at Eur Heart J 2018