Physicians' Academy for Cardiovascular Education

Elevated Lp(a) associated with higher CAC score in individuals with family history of ASCVD

Elevated Lipoprotein(a) levels are associated with coronary artery calcium scores in asymptomatic individuals with a family history of premature atherosclerotic cardiovascular disease

Literature - Verweij SL, de Ronde MWJ, Verbeek R et al. - J Clin Lipidol 2018; published online ahead of print

Main results

Conclusion

In asymptomatic individuals with a family history of ASCVD, elevated Lp(a) levels were associated with higher CAC score, both absolute and, age and gender-corrected CAC score percentiles, independent of CV risk factors. These data support the current EAS recommendation to measure Lp(a) in individuals with family history of premature ASCVD to identify subclinical atherosclerosis in healthy family members. For primary prevention, statin therapy could be started in these individuals with elevated Lp(a).

References

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Find this article online at J Clin Lipidol 2018

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