Higher childhood BMI associated with increased risk of cardio-metabolic disease later in life
Childhood BMI and Adult Type 2 Diabetes, Coronary Artery Diseases, Chronic Kidney Disease, and Cardiometabolic Traits: A Mendelian Randomization AnalysisLiterature - Geng T, Smith CE, Li C, et al. - Diabetes Care 2018; published online ahead of print
- None of the SNPs was found to be in linkage disequilibrium (LD) with each other at an r2 > 0.05, and the results were not influenced by pleiotropy.
- A one-SD increase in childhood BMI (kg/m2) was associated with a substantial increase in risk of T2DM, ranging from 47% (95%CI: 1.18-1.82; P=4.0x10-4) to 83% (95%CI: 1.46-2.30; P=2.5x10-7) dependent on the MR method used, and a 28% increase in risk of CAD (95%CI: 1.17-1.39; P=2.1x10-8).
- Childhood BMI was not associated with adult CKD (OR: 1.14; 95%CI: 0.99-1.31; P=0.076).
A one-SD increase in childhood BMI was causally associated with a:
- 0.587-SD increase in BMI (β: 0.587; 95%CI: 0.458-0.716; P=4.9x10-18)
- 0.062-SD increase in hip circumference adjusted BMI (β: 0.062; 95%CI: 0.025-0.099; P=0.001)
- 0.602-SD increase in waist circumference adjusted BMI (β: 0.602; 95%CI: 0.370-0.834; P=4.8x10-7)
- 0.111 pmol/L increase in log fasting insulin (β: 0.111; 95%CI: 0.065-0.157; P=2.7x10-6)
- 0.068 increase in log HOMA-B (β: 0.068; 95%CI: 0.026-0.110; P = 0.001)
- 0.126 increase in log HOMA-IR (β: 0.126; 95%CI: 0.085-0.168; P=4.7x10-9)
- 0.109-SD increase in triglycerides (β: 0.109; 95%CI: 0.058-0.160; P=3.0x10-5)
- 0.138-SD decrease in HDL (β: 20.138; 95%CI: 20.207-20.069; P=9.3x10-5)
A genetic predisposition to higher childhood BMI was associated with an increased risk of T2DM, CAD, and cardio-metabolic traits in adult life. These results show that there is a substantial public health impact of childhood BMI modification.