Physicians' Academy for Cardiovascular Education

Genetic information to guide antiplatelet selection after ACS can improve outcomes

THE PHARMCLO STUDY: A Prospective, Randomised, Multicentre Study Of A Pharmacogenomic Approach To The Selection Of Antiplatelet Therapy In Acute Coronary Syndromes

Presented at ACC.18 by Diego Ardissino (Azienda Ospedaliero - Universitaria di Parma, Italy)

News - Mar. 11, 2018

Main results

Conclusion

This study showed that the implementation of genotyping to guide the antiplatelet therapy in ACS is feasible across different institutions and that it resulted in different prescribing patterns. A more personalized approach to the selection of antiplatelet therapy may lead to a clinically meaningful reduction in ischemic and bleeding complications. Future studies of genotype-guided antiplatelet therapy should confirm these data and clarify the cost-efficacy of genotyping in the challenging setting of ACS.

In a press release, the presenter Diego Ardissino said “PHARMCLO is the first step of a new approach that will see a shift in emphasis away from trying to discover ever more potent antithrombotic drugs and toward ensuring that the right therapy is given to each individual patient.” And, “As genotyping to select P2Y12 receptor antagonists in the setting of acute coronary syndromes cannot be delegated to centralized genetic laboratories for reasons of time, we designed the ST Q3 instrument for bedside genotyping as a low-cost, portable system for foolproof use by unskilled personnel,” Ardissino said.

Disclosures

Our coverage of ACC.18 is based on the information provided during the congress.

This study was published simultaneously in JACC

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