Physicians' Academy for Cardiovascular Education

Clinical trials in diabetes and CVD: What did we learn?

Expert Meeting on CVD & T2DM

10' education - Mar. 22, 2018 - Filippo Crea, Angelyn Bethel, Eduard Montanya - Online CME

Filippo Crea, Angelyn Bethel and Eduard Montanya discuss the safety and efficacy results of recent trials evaluating GLP-1 RAs and SGLT2 inhibitors, and whether the observed effects represent a class effect or not.

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  • What do the trial results tell us about CV safety and side-effects of GLP-1 RAs? 0:56
  • CV safety and side-effects of SGLT2 inhibitors 2:42
  • Efficacy results vary among the trials with the different GLP1 RA agents 4:47
  • The observed efficacy results with SGLT2 inhibitors may reflect a class effect 6:48
  • GLP-1 RAs and SGLT2 inhibitors seem to positively affect progression of CKD 8:16
  • The novel antidiabetic drugs mark a new era in the treatment of T2DM: what does the future look like? 10:00

Educational information

This video was recorded during a two-day expert meeting among cardiologists and endocrinologists/internists, focussing on the topic of 'Exploring the role of GLP-1 RA in the management of CVD & T2DM'. This video reflects the discussion in the third of five sessions.


Prof. Filippo Crea -cardiologist, Catholic University of the Sacred Heart, Rome, Italy

Prof. Angelyn Bethel - endocrinologist, University of Oxford, United Kingdom

Prof. Eduard Montanya - endocrinologist, University of Barcelona, Spain


This recording was independently developed under auspices of PACE-cme. The views expressed in this recording are those of the individual presenters and do not necessarily reflect the views of PACE-cme.


Funding for the Expert Meeting was provided by an unrestricted educational grant from Novo Nordisk. The sponsor did not attend and influence the meeting or the video recording.

Also see; Novel diabetes drugs in clinical management: Extending the opportunities Also see: What is the science driving CVD and T2DM?


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