Physicians' Academy for Cardiovascular Education

LDL-c lowering with twice-a-year injection of siRNA against PCSK9: The ORION-11 trial

10' education - Sep. 16, 2019 - Prof. John Kastelein - Amsterdam, The Netherlands

Video navigation menu

  • Background and rationale for investigating siRNA directed against PCSK9 00:36
  • ORION-11: Design, inclusion criteria and objectives 01:50
  • Efficacy results over 18 months 04:10
  • Safety and tolerability results 05:57
  • What are the implications of these results? 08:58

Educational information

This video was recorded at ESC 2019 in Paris, France, on September 2, 2019.


Prof. John Kastelein, MD – Emeritus Professor of Medicine at the Department of Vascular Medicine at the Academic Medical Center (AMC) of the University of Amsterdam, where he held the Strategic Chair of Genetics of Cardiovascular Disease.


This recording was independently developed under auspices of PACE-cme. The views expressed in this recording are those of the individual presenter and do not necessarily reflect the views of PACE-cme.

Read our news article on the ORION-11 trial

The content is aimed for medical professionals. To view this item member registration is needed. Register for free to get unlimited access to our educational resources.
The information and data provided in this program were updated and correct at the time of the program development, but may be subject to change.

Share this page with your colleagues and friends: