Physicians' Academy for Cardiovascular Education

Use of in-hospital anticoagulation and mortality in hospitalized COVID-19 patients

Association of Treatment Dose Anticoagulation with In-Hospital Survival Among Hospitalized Patients with COVID-19

Literature - Paranjpe I, Fuster V, Lala A, et al. - J Am Coll Cardiol 2020, doi:

Introduction and methods

High incidence of thrombotic complications have been observed in hospitalized COVID-19 patients [1,2]. There are anecdotal observations of improved outcomes with systemic anticoagulation, but the role of anticoagulation in management of COVID-19 patients is not known [3,4]. Therefore, this study examined the association between use of in-hospital anticoagulation and survival in a large cohort of COVID-19 patients.

Of 2773 hospitalized COVID-19 patients within the Mount Sinai Health System in New York City between March 14 and April 11, 2020, 786 (28%) patients received anticoagulation during hospital stay.

Main results


The authors conclude that these findings suggest that systemic anticoagulation may be associated with improved outcomes in patients hospitalized with COVID-19. They note, however, that benefit of systemic anticoagulation needs to weighted against risk of bleeding. The association between administration of anticoagulation and mechanical ventilation likely reflects more severe clinical presentation of patients who require anticoagulation.


Show references

Find this article online at J Am Coll Cardiol.

Share this page with your colleagues and friends: