Physicians' Academy for Cardiovascular Education

Hemorrhagic stroke related to increased mortality and disability in patients with AF

News - Mar. 23, 2021

Hemorrhagic Strokes in Patients With Atrial Fibrilliation: The Neuro-AFib Study

Presented at the International Stroke Conference 2021 by Edip Gurol (Boston, MA, USA)

Introduction and methods

There is little information about the frequency and causes of ischemic strokes (IS) and hemorrhagic strokes (HS) in patients with AF. The neuro-AFib study is an ongoing multicentered study that focuses on causes and mechanisms of IS and HS and the current management and long-term outcomes in patients with AF. The investigator sponsored research study is conducted in 25 stroke/neurology departments in North America and has enrolled a total of ~10,000 patients in retrospective and prospective phases over 5 years. The retrospective study presented here, analyzed the frequency and failures in the prevention of acute IS of HS in patients with AF (n=6195) who were admitted to the hospital (16 sites) with an acute stroke (IS or HS) from January 2018 to December 2019.

Main results


These preliminary results from the Neuro-AFib study showed significantly worse outcomes for HS compared to IS in patients with AF. In-hospital case fatality with HS was ~3.5 times higher compared to IS and these patients had an increased risk for a severe disability.

– Our reporting is based on the information provided during ISC 2021 –

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