Physicians' Academy for Cardiovascular Education

Taking the long and total view in new AHA CV risk equations

News - Nov. 12, 2023

Novel prediction equations for absolute risk assessment of total CVD incorporating CKM health

Presented at the AHA Scientific Sessions 2023 by: Sadiya Khan, MD - Chicago, IL, US


The 2019 ACC/AHA guidelines on the primary prevention of CVD provide recommendations focusing on risk assessment of CVD for adults age 40-79 years. The framework in these guidelines is used to calculate risk using the pooled cohort equations (PCEs) or the ASCVD risk calculator to identify individuals at high risk.

This risk-based framework continues to be the foundation of how we move forward for prevention, but it has several limitations. First, it was developed only in black and white adults in a relatively small sample and therefore not generalizable to the entire, diverse population. Second, it begins at age 40 and can not be used in younger adults while the burden of cardiovascular-kidney-metabolic syndrome is increasing, particularly in young adulthood. Third, it relies on historical data and the burden of risk factors in the population has changed, as well as treatments.

These gaps were addressed and led to the development of the AHA predicting risk of CVD events – AHA PREVENT™.

Main results

AHA Prevent™

Life course perspective on prediction and prevention

Future directions


The new equations developed by the AHA (the American Heart Association Predicting Risk of Cardiovascular Disease EVENTs; PREVENT™) to assess CVD risk with the inclusion of CKM health focusses on a life course perspective on prediction and prevention of CVD.

- Our reporting is based on the information provided at the AHA Scientific Session 2023 -

Find the publication on the PREVENT equations online at CIrculation Find the publication on the novel equations incorporating CKM health online at CIrculation

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