A prospective study showed an inversed association between nut consumption and incidence of atrial fibrillation and heart failure in the Swedish population.

This review describes six mechanisms underlying HFpEF with potential translational significance; three haemodynamic mechanisms and cellular/molecular mechanisms.

ADA 2018 In the OBSERVE-4D real world study, canagliflozin did not result in increased risk of below-knee amputation in T2DM patients or patients with established CVD.

In a pooled analysis of databases of 6 different countries, the initiation of SGLT2i was associated with lower risks of CV outcomes, as compared with other glucose-lowering drugs.

In type 2 diabetes patients with a recent acute coronary syndrome, NT-proBNP concentrations and absolute changes therein identified those at high risk for adverse CV outcomes, including heart failure.

Type 2 diabetic patients treated with SGLT2i had a lower risk of death and HF when compared with other glucose-lowering drugs, regardless of the presence of CVD.

In a prospective study the risk of all-cause death was comparable in HFpEF and HFmrEF, which was lower than in HFrEF patients. Mortality and HFH were lowest HFpEF patients.

ESC 2018 In this debate, it became clear that not all are convinced yet about the use of the new ejection fraction category HFmrEF that was introduced in the latest ESC HF Guidelines in 2016.

ESC HF 2018 A network meta-analysis showed that incremental use of disease-modifying therapies lowers hospitalizations and mortality, which supports guideline recommendations.

ESC HF 2018 Playing of video games that require rigorous physical exercise yielded significant effects on exercise capacity and well-being in some HF patients.

ESC HF 2018 A large study on individual patient data shows that diabetic HF patients who are not obese have the highest mortality. Obesity attenuates the prognostic impact of beta-blockers.

ESC HF 2018 The REPORT-HF registry allows prospective and longitudinal analyses across seven regions in the world. Patients with acute heart failure are not the same everywhere, which affects therapy.