VBWG at ACC 2018 After lack of sham-controlled trials, the SPYRAL program has started to test the efficacy of renal denervation in patients with uncontrolled hypertension. Two pilot studies with a sham controlled group in patients without and with medications are nearly finished.
Patients with hypertension with low platelet counts and high total homocysteine levels, which may promote platelet adherence, had the highest risk of first stroke, and this risk was reduced with folic acid treatment.
24-hour, daytime, and nighttime ambulatory systolic blood pressure measurements were better predictors of all-cause and CV mortality compared with blood pressure measurements in the clinic.
Obesity in childhood that persists or worsens during adulthood is associated with higher risks of developing hypertension, T2DM, and dyslipidemia.
Based on the new blood pressure definitions for children, the estimated population prevalence of hypertension in individuals aged 5-18 years increased from 11.8% to 14.2%.
In the SPRINT study, a diastolic BP threshold of <55 mmHg was associated with increased cardiovascular events in both patients with and without cardiovascular disease.
ACC 2018 Black barbershops and pharmacists worked together to improve high BP in non-hispanic black men. In a randomized design, a pharmacist intervention led to 27 mmHg drop in SBP over 6 months, vs. 9 mmHg in controls.
Higher BP variability is associated with increased risk of CV events in patients with hypertension, irrespective of CV baseline risk and stronger associations were observed in younger patients and those with lower BP.
Population-based study shows that women with GDM are over 20 times more likely to develop T2DM and have an almost doubled risk of hypertension, and 2.8-fold higher risk of IHD, compared with control.
A meta-analysis shows that the relative benefit of BP-lowering is evident when baseline SBP is ≥140mmHg, but not if it is <140 mmHg, particularly in primary prevention.
AHA 2017 Prof. Clyde Yancy summarizes the most important new recommendations, starting with a new definition of hypertension, the need for a risk conversation and implications for therapy.
AHA 2017 In the SPRINT study, BP was not always measured in absence of a physician or nurse. A posthoc survey investigated whether this affected the findings of the study.