PCSK9 inhibitors: From bench to bedside

PCSK9 Expert Opinions Prof. Gilles Lambert describes the development of PCSK9 inhibitors since the discovery in 2002 of PCSK9 as a circulating protein targeting the LDL receptor for degradation. Now in 2017, results of outcome trials with a PCSK9 inhibitor are available.

• A long road since the discovery of PCSK9, a circulating protein targeting the LDL receptor for degradation  00:23
• Cardiovascular benefits of PCSK9 loss of function mutations  02:22
• Development of PCSK9 inhibitors 02:56
• Lowering LDL-c and Lp(a) by inhibiting PCSK9 with mAbs 04:01
• Results of PCSK9 outcome trials  05:18

Educational information

This educational video is part of a series of PCSK9 Expert Opinions that are aimed to provide different perspectives and opinions from international experts in this field and may provide support with the interpretation and translation of new findings towards implications for clinical practice

The educational content reflects the personal opinion of the experts and is recorded as an independent educational service by PACE-CME

Faculty & Disclosures

Prof. Gilles Lambert – Université de la Réunion, Sainte-Clotilde, France

Funding

Funding was provided by an unrestricted educational grant from Amgen