Epigenetic mechanisms targeting ALP: A pathway for prevention of vascular calcification?
Epigenetic processes are involved in renal damage. Marta Ruiz-Ortega describes the role of vascular calcification and alkaline phosphatase (ALP) in CKD and effects of BET inhibition on vascular calcification.
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- Epigenetic mechanisms are involved in renal damage 00:20
- BET proteins / BET inhibitors and acetylation in gene transcription regulation 01:20
- Vascular calcification and the role of alkaline phosphatase in chronic kidney disease 04:47
- Could BET inhibition be a potential therapeutic strategy to reduce vascular calcification? 06:07
- Other factors involved in CKD that can induce epigenetic changes 10:45
- The effect of BET inhibitors on other transcription factors 12:38
This lecture by dr. Marta Ruiz-Ortega, was part of a CME accredited symposium "Vascular calcification in kidney disease: Epigenetics as a novel approach?" held during ERA-EDTA 2019 in Budapest, Hungary.
Marta Ruiz-Ortega, PhD is Professor at the Faculty of Medicine, Universidad Autónoma de Madrid, Spain.
This recording was independently developed under auspices of PACE-cme. The views expressed in this recording are those of the individual presenter and do not necessarily reflect the views of PACE-cme.
Funding for this educational program was provided by an unrestricted educational grant from Resverlogix.