Physicians' Academy for Cardiovascular Education

Epigenetic mechanisms targeting ALP: A pathway for prevention of vascular calcification?

10' education - Aug. 7, 2019 - Marta Ruiz-Ortega, PhD – Madrid, Spain

Epigenetic processes are involved in renal damage. Marta Ruiz-Ortega describes the role of vascular calcification and alkaline phosphatase (ALP) in CKD and effects of BET inhibition on vascular calcification.

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  • Epigenetic mechanisms are involved in renal damage 00:20
  • BET proteins / BET inhibitors and acetylation in gene transcription regulation 01:20
  • Vascular calcification and the role of alkaline phosphatase in chronic kidney disease  04:47
  • Could BET inhibition be a potential therapeutic strategy to reduce vascular calcification?  06:07
  • Other factors involved in CKD that can induce epigenetic changes 10:45
  • The effect of BET inhibitors on other transcription factors 12:38

Educational information

This lecture by dr. Marta Ruiz-Ortega, was part of a CME accredited symposium "Vascular calcification in kidney disease: Epigenetics as a novel approach?" held during ERA-EDTA 2019 in Budapest, Hungary.


Marta Ruiz-Ortega, PhD is Professor at the Faculty of Medicine, Universidad Autónoma de Madrid, Spain.


This recording was independently developed under auspices of PACE-cme. The views expressed in this recording are those of the individual presenter and do not necessarily reflect the views of PACE-cme.


Funding for this educational program was provided by an unrestricted educational grant from Resverlogix.

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