Physicians' Academy for Cardiovascular Education

Epigenetic mechanisms targeting ALP: A pathway for prevention of vascular calcification?

10' education - Aug. 7, 2019 - Marta Ruiz-Ortega, PhD – Madrid, Spain

Epigenetic processes are involved in renal damage. Marta Ruiz-Ortega describes the role of vascular calcification and alkaline phosphatase (ALP) in CKD and effects of BET inhibition on vascular calcification.

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  • Epigenetic mechanisms are involved in renal damage 00:20
  • BET proteins / BET inhibitors and acetylation in gene transcription regulation 01:20
  • Vascular calcification and the role of alkaline phosphatase in chronic kidney disease  04:47
  • Could BET inhibition be a potential therapeutic strategy to reduce vascular calcification?  06:07
  • Other factors involved in CKD that can induce epigenetic changes 10:45
  • The effect of BET inhibitors on other transcription factors 12:38

Educational information

This lecture by dr. Marta Ruiz-Ortega, was part of a CME accredited symposium "Vascular calcification in kidney disease: Epigenetics as a novel approach?" held during ERA-EDTA 2019 in Budapest, Hungary.

Faculty

Marta Ruiz-Ortega, PhD is Professor at the Faculty of Medicine, Universidad Autónoma de Madrid, Spain.

Disclosures

This recording was independently developed under auspices of PACE-cme. The views expressed in this recording are those of the individual presenter and do not necessarily reflect the views of PACE-cme.

Funding

Funding for this educational program was provided by an unrestricted educational grant from Resverlogix.

View slides of the presentation

The information and data provided in this program were updated and correct at the time of the program development, but may be subject to change.

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