Physicians' Academy for Cardiovascular Education

How can triglycerides increase CV risk?

10' education - Jan. 16, 2020 - Prof. Børge Nordestgaard, MD – Copenhagen, Denmark

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  • Content of plasma lipoproteins  01:03
  • Triglycerides as CV risk factor 02:39
  • Levels of triglycerides in the general population 04:45
  • Mechanisms by which triglycerides and cholesterol can lead to CV events 06:51
  • Lowering cholesterol and triglycerides to 'normal' levels 09:25

How can high triglyceride levels result in increased CV risk?

  • A. Large TG-rich lipoproteins, like chylomicrons, can cross the arterial wall and cause inflammation in the intima
  • B. TG-rich lipoproteins, like remnants, can not cross the arterial wall, but cause inflammation of endothelial cells
  • C. TGs can be degraded by lipoprotein lipase in the intima to free fatty acids and monoacylglycerol, causing inflammation
  • D. TGs can be degraded by hepatic lipase to circulating free fatty acids and monoacylglycerol, causing atherosclerosis
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Educational information

This educational video is part of a series called '4 Things a cardiologist needs to know about triglycerides' that is aimed to guide cardiologists in how triglycerides affect CV risk and how patients with high triglyceride levels can be managed according to recent insights.

Faculty

Prof. Børge Nordestgaard, MD - Professor, University of Copenhagen, Denmark/ Chief Physician, Dept. Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital Denmark

Disclosures

This educational series is funded by an unrestricted educational grant provided by Amarin.

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