Clinical inertia in CKD - What is the rationale for SGLT2i?
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Janaka Karalliedde gives an overview of trials and guidelines that provide evidence for using SGLT2 inhibitors to improve outcomes in patients with CKD.
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CKD is underdiagnosed in T2DM 01:53
Kidney outcomes in SGLT2i CV outcome trials 03:37
Cardiac benefits of SGLT2i in patients with CKD 05:31
Reno-protective effects of SGLT2i in people with T2DM and HFrEF 06:18
Diabetes guidelines and KDIGO guidelines 07:57
Conclusions 10:49
What is true about the outcomes of the EMPA-REG OUTCOME trial?
- A. SGLT2i empagliflozin reduced kidney outcomes (evaluated as secondary outcomes) by 26%
- B. Empagliflozin reduced time to CV death by 29% in patients with diabetes and prevalent kidney disease
- C. The trial showed that empagliflozin has cardioprotective effects, but no reno-protective effects
Educational information
This lecture by Janaka Karalliedde was part of the EBAC-accredited symposium "SGLT2i in CKD: How to overcome clinical inertia?" held during the virtual ERA EDTA 2021 congress.
Faculty
Janaka Karalliedde MD, PhD is a clinical senior lecturer in the School of Cardiovascular Medicine & Sciences at King's College London, and a consultant in diabetes, endocrinology and internal medicine at Guy’s and St Thomas’ Hospital London.
Disclosures
This recording was independently developed under auspices of PACE-cme. The views expressed in this recording are those of the individual presenter and do not necessarily reflect the views of PACE-cme.
Funding
Funding for this educational program was provided by an unrestricted educational grant from Boehringer Ingelheim/Lilly.
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