Thrombosis

ACC 2018 Treatment with dabigatran significantly reduced the risk of thrombotic complications in patients with MINS, as identified by hsTnT level, in the MANAGE study.

Background

MINS refers to myocardial injury after noncardiac surgery, and includes myocardial infarction (MI) and is...

Overweight and obese individuals have a significantly increased long-term risk for CVD morbidity, and a similar or shorter total longevity, compared with individuals with a normal BMI.

In young asymptomatic individuals with family history of premature ASCVD, elevated Lp(a) is related to higher CAC score, resulting in the identification of individuals with subclinical atherosclerosis.

In patients with atrial fibrillation on oral anticoagulation, higher ApoA1 levels were associated with a lower risk of stroke, systemic embolism, and all-cause and CV mortality.

In patients with ischemic stroke ≥ 65 years, diabetes is associated with a higher risk of mortality, recurrent events, HF and hospitalisations.

Patients with a history of MI and MVD are at increased risk for MACE and coronary events compared to those without MVD and benefit from long-term ticagrelor therapy.

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//PCSK9// genetic variants, that produce lower levels of LDL-c, are not associated with the risk of ischemic stroke, in contrast to significant association with the risk of CHD.

Background

Low-density lipoprotein cholesterol (LDL-...

A large meta-analysis showed that omega-3 fatty acid supplementation is not associated with a reduction in fatal and non-fatal CHD and other major vascular events.

Higher BP variability is associated with increased risk of CV events in patients with hypertension, irrespective of CV baseline risk and stronger associations were observed in younger patients and those with lower BP.

The relation between smoking and CV risk is non-lineair: smoking 1 cigarette/day is associated with 30-50% of the excess risk of coronary heart disease and stroke when smoking 20 cigarettes/day.

In a community-based cohort, higher resting heart rate and increased changes in resting heart rate over time were associated with mortality, incident heart failure, myocardial infarction, and stroke.

Treatment with low-dose rivaroxaban plus aspirin resulted in a reduction of major CV events compared to aspirin in patients with stable CAD and reduced major adverse limb events in patients with PAD.

Connolly SJ, Eikelboom JW, Bosch J,

Meta-analysis shows that in patients with recent ACS, addition of a NOAC to dual antiplatelet therapy resulted in a modest reduction of major adverse CV events but led to higher bleeding risk.

Two documents summarize the main messages of the ESC 2017 STEMI management guidelines, namely changes with respect to the 2012 version and ‘ten commandments’ to follow.

The European Heart Journal now published two documents summarizing the major messages of the “2017 ESC Guidelines for the management of acute myocardial infarction in patients pres...

In a longitudinal 40-years follow-up, the impact of 8 traditional CV risk factors on CVD declined with aging, with the exception of LDL-c for MI, and BMI and fasting glucose for HF.

Background

Traditi...

In a prospective community-based cohort, Lp(a) ≥50 mg/dL was associated with higher stroke risk in those without AF, but not in those with AF, nor with an elevated risk of AF.